Scientific paper as a poem

January 28, 2013

Gramicidin S Interrogation

gramicidin

gramicidin S was not like his fellow gramicidins
There was nothing linear about him

Two identical pentapeptides joined head to tail
Synthesized by gramicidin S synthetase

He was recruited for antibiotic duty in 1942
Fighting against bacteria and some fungi too

His fighting technique was well known in vivo
Binding with phospholipids of cell membranes was the way to go

In silico GS was more of a mystery man
Perhaps his intrinsic and native structure could reveal his plan

Know your enemy is what Machiavelli and Sun Tzu say
Maybe GS will reveal all with molecular H-bonding interplay

A good place to start is gas phase isolation
Progressive water(molecule)boarding helps control interaction

Add a bit of cryogenic cooling to avoid thermal congestion
A unique spectroscopic fingerprint is the final destination

GS he seemed like such a tough guy
But it took only 2 water molecules to make him cry

The complex stereoscopic fingerprint of GS was cracked
With these constraints it should be easy for the theorists to attack.

REFERENCES

Nagornova NS, Rizzo TR and Boyarkin OV (2012) Interplay of Intra- and Intermolecular H-Bonding in a Progressively Solvated Macrocyclic Peptide . Science 336, 320; DOI: 10.1126/science.1218709

Image credit: Wikipedia Commons

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: